I would like to thank Francisco Conceição, Helena Martins and Joãoįrancisco for all the support they gave me when I was in Lisbon and for always being threįor me. I must mention, and express my appreciation to, some of my friends who have always Opportunity to achieve this new and important academic degree. Leuenberger from the Hospital Centre of Biel in Switzerland for granting me the I would like to express my gratitude to Doctor Marianne Braunschweig and Renato I would like to thank Professor Ana Luisa Vieira, Ph.D for her patience, friendship and
Sincere interest and passion for the search of knowledge will always stay with me as Thank André Santos Ribeiro and Ricardo Maximiano for their time, effort and advice. Me, that I am ready to continue my long journey in this wonderful field. I am sure, with the guidance he has given
Self-determination and support he has provided. Like to thank my advisor, Professor Doctor Hugo Alexandre Ferreira, for the opportunity, Undertaken without the support of many members of my family and friends. This dissertation is the result of dedication and continuous effort and could not have been
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